Treatment of Glomerular Diseases: Pioneering Clinical Trials

Celebrating ISN’s 60th anniversary, Kidney International’sMilestones in Nephrology” series continues with a review of some of the original articles it has published on the treatment of glomerular disease, publications that helped make significant changes in patient management:

  • Shorter term corticosteroids are equally effective as longer term in primary nephrotic syndrome in children (Yoshikawa N, Nakanishi K, Sako M, et al.)
  • Calcineurin inhibitors in focal segmental glomerulosclerosis and membranous nephropathy (Cattran DC, Appel GB, Hebert LA, et al.)
  • High-dose melphalan and autologous stem cell transplantation is feasible in end-stage kidney failure patients with amyloid light-chain (AL) amyloidosis (Casserly LF, Fadia A, Sanchorawala V, et al.)
  • Renal effects of enzyme replacement therapy in Fabry disease (FD) (Thurberg BL, Rennke H, Colvin RB, et al.)

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