The first decade of Kidney International: Treasure hunt for the kidney tubule

To celebrate ISN’s 60th anniversary, Kidney International’s “Milestones in Nephrology” series continues with a review of five foundational contributions related to various tubular segments in the normal and diseased kidney:

• Model for bicarbonate and fluid reabsorption in the proximal tubule (McKinney TD, Burg MB., 1977)
• Intralysosomal digestion of endocytosed proteins in proximal tubule cells (Christensen EI, Maunsbach AB., 1974)
• The countercurrent multiplication system in the medulla (Kokko JP, Rector FC Jr., 1972)
• Treatment of Bartter syndrome with indomethacin (Verberckmoes R, van Damme BB, Clement J, et al., 1976)
• Plasticity in the distal nephron following acid-base modifications (Hagége J, Gabe M, Richet G., 1974)