Dialysis: learning dialysis through computation, experimentation, and implementation

As part of ISN’s 60th-anniversary, Kidney International’s “Milestones in Nephrology” series highlights five significant contributions toacute kidney injury, diabetic kidney disease, and cell biology:

• Glomerular hemodynamics in experimental diabetes mellitus(Hostetter TH, Troy JL, Brenner BM, 1981)

• Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial (The Diabetes Control and Complications Trial (DCCT) Research Group, 1995)

• Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury (Han WK, Bailly V, Abichandani R, et al. 2002)

•  HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney(Ryan MJ, Johnson G, Kirk J, et al. 1994)

• Identification of the renal erythropoietin-producing cells using transgenic mice (Maxwell PH, Osmond MK, Pugh CW, et al. 1993)